← Back to all articles
Depression & MoodDOI ResolvedOpen Access

The therapeutic potential of ayahuasca in depression, generalized anxiety, and substance use disorders: modulation of the depressive burden in a longitudinal study

Camargos GS, de Faria Júnior GM, Lourenço M, de Araújo Filho GM

Frontiers in psychiatry (2026)

Longitudinal observational
Abstract

INTRODUCTION: This longitudinal observational study evaluated changes in depressive symptoms associated with ritualistic ayahuasca use in patients diagnosed with depressive disorders, as well as depressive burden in individuals with anxiety and substance use disorders. METHODS: The research was conducted with 280 adults treated at clinics in the...

Study TypeLongitudinal observational
ayahuascamental disorderspsychedelicspsychotherapy
DOI: 10.3389/fpsyt.2026.1726909View on PubMed

Related Articles

Depression & Mood

LGBTQ+ Ayahuasca Retreat Experience is Associated with Benefits to Mental Health, Quality of Life, and Spiritual Well-Being: A Prospective, Naturalistic Study

Lowe MX, Darby QA et al.

Journal of psychoactive drugs, 2026
Depression & Mood

Predicting drug-drug interactions between ayahuasca alkaloids and SSRIs using physiologically based pharmacokinetic modeling

Ribeiro GSG, Paranhos BAPB et al.

Frontiers in molecular biosciences, 2026
Clinical Trials

Ayahuasca and Its Main Component N,N-Dimethyltryptamine (DMT) for the Treatment of Mental Disorders: Mechanisms of Action, Clinical Studies, and Tools to Explore the Human Mind

Melani A, Papini G et al.

Biomedicines, 2026
Psychology

Ayahuasca and Public Health III: Health Status of a Sample of Ayahuasca Ceremony Attenders in Portugal

Teixeira PJ, Encantado J et al.

Journal of psychoactive drugs, 2026