← Back to all articles
Clinical TrialsPubMed VerifiedOpen Access

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Osorio FL, Sanches RF, Macedo LR, dos Santos RG, Maia-de-Oliveira JP, Wichert-Ana L, de Araujo DB, Riba J, Crippa JA, Hallak JE

Revista Brasileira de Psiquiatria (2015)

Open-label trial
Abstract

Open-label trial in 6 patients with recurrent depression. Significant reductions in depression scores within hours, persisting for 21 days. First clinical study of ayahuasca's antidepressant potential.

Participants6
Citations360
Study TypeOpen-label trial
depressionopen-labelantidepressant
DOI: 10.1590/1516-4446-2014-1496View on PubMed

Related Articles

Clinical Trials

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a SPECT study

Sanches RF, de Lima Osorio F et al.

Journal of Clinical Psychopharmacology, 2016
Clinical Trials

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Palhano-Fontes F, Barreto D et al.

Psychological Medicine, 2019
Reviews

Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies

Dos Santos RG, Osorio FL et al.

Revista Brasileira de Psiquiatria, 2016
Clinical Trials

Ayahuasca and Its Main Component N,N-Dimethyltryptamine (DMT) for the Treatment of Mental Disorders: Mechanisms of Action, Clinical Studies, and Tools to Explore the Human Mind

Melani A, Papini G et al.

Biomedicines, 2026