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Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Palhano-Fontes F, Barreto D, Onias H, Andrade KC, Novaes MM, Pessoa JA, Mota-Rolim SA, Osorio FL, Sanches R, dos Santos RG, Tofoli LF, Silveira GO, Yonamine M, Riba J, Santos FR, Silva-Junior AA, Alchieri JC, Galvao-Coelho NL, Lobao-Soares B, Hallak JEC, Arcoverde E, Maia-de-Oliveira JP, Araujo DB

Psychological Medicine (2019)

Randomized Controlled Trial
Abstract

First randomized placebo-controlled trial of ayahuasca for treatment-resistant depression. 29 patients received a single dose. Significant antidepressant effects at all time points with Cohen's d = 1.49 at day 7. Response rate 64% vs 27% placebo.

Participants29
Citations500
Study TypeRandomized Controlled Trial
depressiontreatment-resistantRCTplacebo-controlled
DOI: 10.1017/S0033291718001356View on PubMed

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