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Depression & MoodPubMed VerifiedOpen Access

Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls

Galvao ACM, de Almeida RN, Silva EAS, Freire FAM, Palhano-Fontes F, Onias H, Arcoverde E, Maia-de-Oliveira JP, de Araujo DB, Lobao-Soares B, Galvao-Coelho NL

Frontiers in Psychiatry (2018)

Secondary analysis of RCT
Abstract

Explored cortisol modulation in treatment-resistant depression patients and healthy controls. Found blunted cortisol awakening response normalized 48h after ayahuasca, suggesting HPA axis modulation as a therapeutic mechanism.

Participants28
Citations90
Study TypeSecondary analysis of RCT
cortisolHPA axisdepressionstress response
DOI: 10.3389/fpsyt.2018.00185View on PubMed

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