← Back to all articles
Depression & MoodPubMed VerifiedOpen Access

Cortisol modulation by ayahuasca in patients with treatment resistant depression and healthy controls

Galvao ACM, de Almeida RN, Silva EAS, Freire FAM, Palhano-Fontes F, Onias H, Arcoverde E, Maia-de-Oliveira JP, de Araujo DB, Lobao-Soares B, Galvao-Coelho NL

Frontiers in Psychiatry (2018)

Secondary analysis of RCT
Abstract

Explored cortisol modulation in treatment-resistant depression patients and healthy controls. Found blunted cortisol awakening response normalized 48h after ayahuasca, suggesting HPA axis modulation as a therapeutic mechanism.

Participants28
Citations90
Study TypeSecondary analysis of RCT
cortisolHPA axisdepressionstress response
DOI: 10.3389/fpsyt.2018.00185View on PubMed

Related Articles

Depression & Mood

Moderators of ayahuasca's biological antidepressant action

Sousa GM, de Oliveira Tavares VD et al.

Frontiers in Psychiatry, 2022
Depression & Mood

Acute effects of ayahuasca in a juvenile non-human primate model of depression

da Silva FS, Silva EAS et al.

Behavioural Brain Research, 2019
Depression & Mood

Beyond Enthusiasm: Ayahuasca and the Future of Depression Research

Sá Filho AS, Fajemiroye JO et al.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2026
Depression & Mood

A quantitative textual analysis of the subjective effects of ayahuasca in naive users with and without depression

Cruz L, Bienemann B et al.

Scientific Reports, 2023