Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors

Comprehensive review of DMT neurobiology from ayahuasca to synthetic MAO inhibitor combinations. Covers receptor pharmacology, neuroimaging, electrophysiology, and clinical data. Discusses the shift from botanical ayahuasca to standardized pharmaceutical-grade DMT/harmine formulations for clinical trials.