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Personality, not cognition, distinguishes chronic ayahuasca and cannabis users from non-users

Bouso JC, Andion O, Fondevila Estevez S, Cutchet M, Riba J, Fernandez X, Alcazar-Corcoles MA

European Neuropsychopharmacology (2026)

Cross-sectional controlled
Abstract

Controlled comparison of 69 chronic ayahuasca users, 56 cannabis users, and 94 non-users. Found no significant neuropsychological performance differences. Ayahuasca users showed distinctively higher self-transcendence personality scores, suggesting long-term ceremonial use does not impair cognition.

Participants219
Study TypeCross-sectional controlled
cognitionpersonalityself-transcendencechronic usersneuropsychology
DOI: 10.1016/j.euroneuro.2026.112782View on PubMed

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