The endogenous hallucinogen and trace amine N,N-dimethyltryptamine displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells

Demonstrated that DMT protects human cortical neurons and microglia-like immune cells against severe hypoxia via sigma-1 receptor activation. Cells pre-treated with DMT showed significantly improved survival under hypoxic stress. Suggests an endogenous protective role for DMT in brain injury.