NeurosciencePubMed VerifiedOpen Access

Human brain effects of DMT assessed via EEG-fMRI

Timmermann C, Roseman L, Haridas S, Rosas FE, Luan L, Kettner H, Martell J, Erritzoe D, Tagliazucchi E, Pallavicini C, Girn M, Alamia A, Leech R, Nutt DJ, Carhart-Harris RL

Proceedings of the National Academy of Sciences (2023)

Experimental neuroimaging

Abstract

First simultaneous EEG-fMRI study of intravenous DMT -- the principal psychoactive compound in ayahuasca -- in humans. Found reduced resting-state network integrity and segregation, increased global functional connectivity, and pronounced changes in default mode, salience, and frontoparietal networks. Results reveal how DMT disrupts canonical brain organization.

Participants20

Citations120

Study TypeExperimental neuroimaging

DMT EEG-fMRI default mode network consciousness neuroimaging

DOI: 10.1073/pnas.2218949120 View on PubMed

Neuroscience