Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-dimethyltryptamine and harmine

First-in-human trial demonstrating that buccal/intranasal DMT-harmine co-administration significantly attenuates nausea and vomiting compared to traditional oral ayahuasca while producing superior, less variable pharmacokinetic profiles. Establishes a clinical-grade alternative for affective disorder trials.