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PsychologyPubMed Verified

Embracing change: impermanence acceptance mediates differences in death processing between long-term ayahuasca users and non-users

David J, Berkovich-Ohana A, Dor-Ziderman Y, Lev-Ran S, Gandy S

Psychopharmacology (2025)

Cross-sectional controlled
Abstract

Comparing 54 long-term ayahuasca users to 53 non-users, found users exhibited lower death anxiety and greater death acceptance. Impermanence acceptance — predicted by ego dissolution intensity — was identified as the key mediating mechanism.

Participants107
Citations5
Study TypeCross-sectional controlled
death anxietyimpermanenceego dissolutiondeath acceptancemeditation
DOI: 10.1007/s00213-025-06792-0View on PubMed

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