← Back to all articles
PsychologyPubMed VerifiedOpen Access

Enhancing mindfulness and compassion through an ayahuasca-inspired formulation containing N,N-DMT and harmine: a randomized controlled trial in healthy subjects

Aicher HD, Wicki IA, Meling D, Mueller MJ, Dornbierer DA, Scheidegger M

Journal of Psychopharmacology (2025)

Randomized controlled trial
Abstract

RCT in healthy subjects showing that a DMT/harmine formulation (ayahuasca analogue) acutely enhances mindfulness and compassion. Findings support the notion that DMT/harmine may have therapeutic potential through enhancing mindfulness and compassion.

Study TypeRandomized controlled trial
mindfulnesscompassionDMTharmineRCT
DOI: 10.1177/02698811251344689View on PubMed

Related Articles

Psychology

Meditating on psychedelics: a randomized placebo-controlled study of DMT and harmine in a mindfulness retreat

Meling D, Egger K et al.

Journal of Psychopharmacology, 2024
Psychology

Investigating Hypo-Egoic Features: Ayahuasca's Psychedelic Path Versus Meditation's Mindful Journey

Arqueros M, Soler J et al.

Human psychopharmacology, 2026
Psychology

A prospective ecological momentary assessment study of an ayahuasca retreat: exploring the salutary impact of acute psychedelic experiences on subacute affect and mindfulness skills in daily life

Sznitman SR, Behar YA et al.

Psychopharmacology, 2025
Pharmacology

Development of a physiologically based pharmacokinetic model of N,N-dimethyltryptamine, harmine, and their interactions from ayahuasca in rats and humans

Wittayakarn N, Tan YM et al.

Toxicological Sciences, 2025