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Preliminary effects of ayahuasca on mental and physical health: a systematic review of prospective studies

Haupt MJ, Carra S, Boehnke KF, Perkins D, Sarris J

Progress in Neuro-Psychopharmacology and Biological Psychiatry (2026)

Systematic review
Abstract

Systematic review of 18 prospective studies finding ayahuasca associated with long-term improvements in depression, psychiatric symptoms, substance misuse, cognitive flexibility, and prosocial behavior. Notes methodological limitations including small samples and lack of control groups.

Study TypeSystematic review
systematic reviewprospective studiesmental healthphysical health
DOI: 10.1016/j.pnpbp.2026.111634View on PubMed

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