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PharmacologyDOI ResolvedOpen Access

Ayahuasca's biological action on the serotonergic system: therapeutic perspectives

Dominguez-Clave E, Soler J, Elices M, Pascual JC, Alvarez E, de la Fuente Revenga M, Friedlander P, Feilding A, Riba J

Frontiers in Pharmacology (2022)

Narrative review
Abstract

Reviews ayahuasca's mechanisms via the serotonergic system. Covers 5-HT2A agonism by DMT, 5-HT reuptake inhibition by THH, MAO-A inhibition by harmine and harmaline, and downstream effects on neuroplasticity and emotional processing. Discusses how serotonergic modulation underlies therapeutic applications for mood disorders.

Citations20
Study TypeNarrative review
serotonergic system5-HT2AMAO-ATHHmood disordersmechanisms
DOI: 10.3389/fphar.2022.1001402Search PubMed

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