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PharmacologyPubMed Verified

Psychedelic compounds as a new approach to treating autoimmune conditions

Flanagan TW, Nichols CD

Immunological Investigations (2018)

Review / hypothesis
Abstract

Proposes that psychedelics including DMT and ayahuasca alkaloids may treat autoimmune conditions through potent anti-inflammatory effects mediated by 5-HT2A receptor activation. Reviews evidence that serotonergic psychedelics suppress TNF-alpha, IL-1beta, and other inflammatory cytokines. Suggests a novel therapeutic application.

Citations95
Study TypeReview / hypothesis
autoimmuneanti-inflammatory5-HT2ATNF-alphaimmunomodulation
DOI: 10.1080/08820139.2018.1474169View on PubMed

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